文献类型：期刊文献

英文题名：Amur Linden Honey and its Principal Components Alleviate Obesity and Regulate Gut Microbiota in High-Fat Diet-Induced Mice

作者：Chen, Zitian[1]; Tao, Heng[1]; Peng, Yuke[1]; Huang, Jiayi[1]; Cheng, Yanzhe[1]; Tian, Wenxuan[1]; Chang, Yaning[1]; Zhou, Yingjun[1,2]

机构：[1] State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, China; [2] State Key Laboratory of Genetic Engineering, Department of Microbiology, Fudan Microbiome Center, School of Life Sciences, Fudan University, Shanghai, 200438, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240456826)

语种：英文

摘要：Obesity seriously affects human health recently, prompting a growing interest in honey as a sugar substitute. However, the persistently high sugar content in honey remains a significant concern, especially for obese individuals. LH-a first-grade honey, was explored as a low GI food. The recommended dosage of LH by the WHO can significantly improve obesity. The nine PC were identified by metabolomics and proven to have anti-obesity activity, which may play a key role in the effects of LH. The anti-obesity effects of LH were more pronounced as compared to the equivalent amount of glucose and fructose, and this effect was further facilitated by addition of the PC. LH and HP (LH with the addition of PC) attenuate obesity by modulating gut-microbiota, promoting SCFAs, activating AMPK/PI3K/AKT pathways. Study revealed that LH has the potential to be a healthy and safe sugar substitutes due to its positive effects on the obesity. ? 2024, The Authors. All rights reserved.