文献类型：期刊文献

英文题名：Borophosphate glass-ceramic scaffolds by a sodium silicate bonding process

作者：Liang, Wen[1];Tu, Yifan[1];Zhou, Huanjun[1];Liu, Changsheng[1];Ruessel, Christian[2]

机构：[1]E China Univ Sci & Technol, Res Inst Biomat, Shanghai 200237, Peoples R China;[2]Univ Jena, Otto Schott Inst, Jena, Germany

年份：2011

卷号：357

期号：3

起止页码：958

外文期刊名：JOURNAL OF NON-CRYSTALLINE SOLIDS

收录：;EI(收录号：20110513635914);WOS:【SCI-EXPANDED(收录号:WOS:000288232500027)】；

基金：The authors wish to acknowledge the valuable discussion with Prof. D E Day in the Materials Research Center, the Missouri University of Science and Technology. This paper is sponsored by the National Nature Science Foundation of China (Project for Young Scientists Fund No. 50902048) and program for Changjiang Scholars and Innovative Research Team in University (IRT0825).

语种：英文

外文关键词：Borophosphate glass; Scaffold; Hydroxyapatite

摘要：A borophosphate glass with the mol% composition 25Na(2)O-25CaO-5P(2)O(3)-45B(2)O(5) was melted. The crystalline phase rheanite crystallized spontaneously during cooling the sample. Porous glass-ceramic scaffolds were prepared by bonding glass particles with size distributions in the range of approximately 100-500 pm by 0.1 M Na2SiO3 solutions. The scaffolds porosities were 40-60% and their compressive strengths were 0.1 similar to 0.4 MPa. The conversion of the binding scaffolds to hydroxyapatite (HA) was investigated by measuring the weight loss after soaking the sample in a solution of 0.25 M K2HPO4 with a pH value of 9.0 at 37 degrees C as a function of time. Hydroxyapatite (HA) was observed by XRD and SEM after soaking for 7 days. Cell attachment, spreading and proliferation on both unconverted scaffolds and on scaffolds coated with HA were determined by MIT [3-(4.5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay method using Murine osteoblastic-like MC3T3-E1 cells. The scaffolds are biocompatible and their biocompatibility is enhanced after the formation of a HA layer. (C) 2010 Elsevier B.V. All rights reserved.