文献类型：期刊文献

英文题名：Novel perfluoroalkyl phthalocyanine metal derivatives: Synthesis and photodynamic activities

作者：Qiu, Tao[1,2];Xu, Xiaoyong[1];Liu, Jianwen[1];Qian, Xuhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Jiangsu Polytech Univ, Inst Fine Chem, Changzhou 213164, Peoples R China

年份：2009

卷号：83

期号：1

起止页码：127

外文期刊名：DYES AND PIGMENTS

收录：;EI(收录号：20092312109063);WOS:【SCI-EXPANDED(收录号:WOS:000267414100016)】；

基金：This work was financial supported by National Natural Science Foundation of China. The authors also thank to the partly support from Shanghai Leading Academic Discipline Project, Project Number (B507), 111 Project (No. 1307023) Shanghai Education Committee and Shanghai Foundation of Science and Technology.

语种：英文

外文关键词：Perfluoroalkyl phthalocyanines; Synthesis; Photosensitizer; Photodynamic therapy; HL-60 leukemic cell; A375 melanotic cancer cell

摘要：Novel perfluoroalkyl phthalocyanine metal derivatives with four perfluorobutyl or four perfluorohexyl groups were synthesized by a two-step procedure starting from 4-iodophthalonitrile: the preparation of the key intermediate 4-(perfluorohexyl)phthalonitrile was optimized. Values of fluorescence quantum yield in ethanol of 0.11 and 0.38 were obtained for zinc(H) tetra (perfluorobutyl)phthalocyanine and zinc(H) tetra (perfluorohexyl) phthalocyanine, respectively. The photodynamic activities of two, zinc (11) phthalocyanine derivatives upon both HL-60 leukemic cells and A375 melanotic cancer cells in vitro were investigated revealed that the cell viability was slightly better in the case of HL-60 than A375. (C) 2009 Elsevier Ltd. All rights reserved.