文献类型：期刊文献

中文题名：过渡金属催化的烯/炔丙基杂原子偶极前体参与的不对称环化反应

英文题名：Transition Metal-Catalyzed Asymmetric Cyclizations Involving Allyl or Propargyl Heteroatom-Dipole Precursors

作者：张键[1,2];陈颖[2];汪全南[1];沈佳欢[2];刘飏子[1];邓卫平[1,2]

机构：[1]浙江师范大学化学与生命科学学院,浙江金华321004;[2]华东理工大学药学院,上海200237

年份：2022

卷号：42

期号：10

起止页码：3051

中文期刊名：有机化学

外文期刊名：Chinese Journal of Organic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000903967500003)】；北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：Project supported by the National Natural Science Foundation of China (Nos. 21971262, 22171082).

语种：中文

中文关键词：过渡金属催化;杂原子偶极;不对称环化

外文关键词：transition metal catalysis;heteroatom dipole;asymmetric cyclization

摘要：手性杂环化合物是一类重要的手性物质,存在于许多手性药物、农药及催化剂中,实现其催化不对称合成一直是有机合成的研究热点.而过渡金属催化的杂原子偶极参与的不对称环化反应是构建该骨架的重要方法.其中,基于过渡金属催化的烯/炔丙基取代反应设计的杂原子偶极前体在近二十年来发展迅速,在该领域占有着重要地位.详细介绍了烯/炔丙基杂原子偶极前体参与的过渡金属催化不对称环化反应,分析了目前方法的优势及存在的问题,以期为从事催化不对称合成及相关领域的研究者提供有益借鉴和参考.
Chiral heterocyclic compounds are an important class of chiral substances,which are widespread in many chiral drugs,pesticides and catalysts.Therefore,the efficient asymmetric synthesis of these compounds becomes a research hotspot in organic synthesis.Transition metal-catalyzed asymmetric cyclization with heteroatom-dipole precursors is an important method to construct these frameworks.Among them,the heteroatom-dipole precursors designed based on transition metal-catalyzed allyl or propargyl substitutions have been extensively studied in the past two decades and occupied an important role in this field.The transition metal-catalyzed asymmetric cyclizations with allyl or propargyl heteroatom-dipole precursors are introduced in detail.The advantages and existing problems of the current methods are analyzed,which would provide useful reference for the researchers in asymmetric synthesis and related fields.