文献类型：期刊文献

英文题名：Recent advances in peptide nucleic acid for cancer bionanotechnology

作者：Wu, Jun-chen[1,2];Meng, Qing-chun[1,2,3];Ren, Hong-mei[1,2,3];Wang, Hong-tao[3];Wu, Jie[4];Wang, Qi[4]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]PetroChina Huabei Oilfield Co, Res Inst Explorat & Dev, Renqiu 062500, Peoples R China;[4]Nantong Univ, Coll Publ Hlth, Nantong 226019, Peoples R China

年份：2017

卷号：38

期号：6

起止页码：798

外文期刊名：ACTA PHARMACOLOGICA SINICA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000402526900006)】；

基金：We thank the National Natural Science Foundation of China (21572057, 91529101 and 21341001) for financial support and the Innovation and Entrepreneurship Training Program of Jiangsu Province (2014105, 201510304036z) for financial support.

语种：英文

外文关键词：peptide nucleic acids; bionanotechnology; cancer diagnostics and therapy

摘要：Peptide nucleic acid (PNA) is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA. In this review, we summarize the recent progresses that have been made in cancer detection and therapy with PNA biotechnology. In addition, we emphasize nanoparticle PNA-based strategies for the efficient delivery of drugs in anticancer therapies.