文献类型：期刊文献

英文题名：3,5-Dicaffeoylquinic acid isolated from Artemisia argyi and its ester derivatives exert anti-Leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects

作者：Zhang, Yan-Hong[1,2];Xue, Mei-Qin[3];Bai, Yuan-Chao[1,2];Yuan, Hui-Hui[1,2];Zhao, Hong-Li[1,2];Lan, Min-Bo[1,2,4]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China;[4]E China Univ Sci & Technol, Minist Chinese Educ Minist, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2012

卷号：83

期号：7

起止页码：1281

外文期刊名：FITOTERAPIA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000309249000018)】；

基金：This work was financially supported by the Science and Technology Commission of Shanghai Municipality (STCSM; No. 08DZ1974000 and No. 10dz2220500). The authors thank Prof. Enduo Wang, Dr. Xiaolong Zhou, Dr. Qinghua Hu and Mr. Daohai Du from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences for providing us the G. lamblia cell line and their useful suggestions during the course of experiments and writing.

语种：英文

外文关键词：3,5-Dicaffeoylquinic acid; Derivatives; Artemisia argyi; Leucyl-tRNA synthetase; Anti-giardial

摘要：An aqueous ethanol extract of Artemisia argyi inhibited the aminoacylation activity of LeuRS from Giardia lamblia (GlLeuRS). The bioassay-guided fractionation of the extract led to the isolation of 3,5-dicaffeoylquinic acid (1), with an IC50 of 5.82 mu g/mL. The ester derivatives of 1 were also found to possess strong anti-GlLeuRS effects, with IC50 values of 1.79, 5.51 and 2.56 mu g/mL respectively. Anti-giardial assay showed that the derivatives, especially 3,5-dicaffeoylquinic acid propyl ester (4) (IC50 =4.62 mu g/mL), were effective at killing G. lamblia. (C) 2012 Elsevier B.V. All rights reserved.