文献类型：期刊文献

英文题名：Dual- channel near- infrared fluorescent probe for real- time tracking of endogenous c- glutamyl transpeptidase activity

作者：Bai, Bing[1];Yan, Chenxu[1];Zhang, Yutao[1];Guo, Zhiqian[1];Zhu, Wei-Hong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, State Key Lab Bioreactor Engn,Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2018

卷号：54

期号：87

起止页码：12393

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000448823200025)】；

语种：英文

摘要：A curcuminoid difluoroboron-based tumor-targeting GGT-activatable fluorescent probe (Glu-DFB-biotin) is designed, which has remarkable characteristics of dual-channel and light-up near-infrared (NIR) fluorescence. Furthermore, Glu-DFB-biotin can differentiate hepatic cancer cells from normal cells and is successfully employed for real-time tracking of endogenous GGT activity in living cells.