文献类型：期刊文献

英文题名：Biocompatible Nanoparticles Based on Diketo-Pyrrolo-Pyrrole (DPP) with Aggregation-Induced Red/NIR Emission for In Vivo Two-Photon Fluorescence Imaging

作者：Gao, Yuting[1,2];Feng, Guangxue[3];Jiang, Tao[1,2];Goh, Chiching[4];Ng, Laiguan[4];Liu, Bin;Li, Bo[3,5];Yang, Lin[1,2];Hua, Jianli[1,2];Tian, He[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Inst Fine Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore;[4]Biopolis, A STAR Agcy Sci Technol & Res, Singapore Immunol Network SIgN, Singapore 138648, Singapore;[5]E China Normal Univ, Minist Educ, Key Lab Polar Mat & Devices, Shanghai 200241, Peoples R China

年份：2015

卷号：25

期号：19

起止页码：2857

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20152100866518);WOS:【SCI-EXPANDED(收录号:WOS:000354626800008)】；

基金：Y.G. and G.F. contributed equally to this work. This work was supported by the National Basic Research 973 Program (2013CB733700 and 2013CB834701), NSFC/China (21421004, 21372082, 21172073, and 91233207), the Singapore JCO (IMRE/14-8P1110), SMART (R279-000-378-592), and the Singapore Ministry of Defense (R279-000-340-232).

语种：英文

外文关键词：Tissue - Photons - Two photon processes - Biocompatibility - Aromatic compounds - Fluorescence imaging

摘要：Compared with traditional one-photon fluorescence imaging, two-photon fluorescence imaging techniques have shown advantages such as increased penetration depth, lower tissue autofluorescence, and reduced photo damage, and therefore are particularly useful for imaging tissues and animals. In this work, the design and synthesis of two novel DPP-based compounds with large two-photon absorption (2PA) cross-sections (sigma >= 8100 GM) and aggregation-induced emission (AIE) properties are reported. The new compounds are red/NIR emissive and show large Stokes shifts (Delta lambda >= 3571 cm(-1)). 1,2-Distearoyl-sn-glycero-3-phosphoethanol amine-N -[ maleimide(polyethylene glycol)-2000 (DSPE-PEG-Mal) is used as the encapsulation matrix to encapsulate DPP-2, followed by surface functionalization with cell penetrating peptide (CPP) to yield DPP-2-CPP nanoparticles with high brightness, good water dispersibility, and excellent biocompatibility. DPP-2 nanoparticles have been used for cell imaging and two-photon imaging with clear visualization of blood vasculature inside mouse ear skin with a depth up to 80 mu m.