文献类型：期刊文献

英文题名：Nanogel-Reinforced Polyacrylamide Hydrogel for Potential Vascular Adhesion

作者：Wang, Tao[1];Zhao, Weijie[1];Wu, Yue[1];Wang, Xiaohan[1];Kayitmazer, Basak[2];Ahmad, Ayyaz[3];Ramzan, Naveed;Si, Yi[4];Wang, Jie[1];Xu, Yisheng[1,5]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkiye;[3]Muhammad Nawaz Sharif Univ Engn & Technol, Dept Chem Engn, Multan 60000, Pakistan;[4]Fudan Univ, Dept Vasc Surg, Zhongshan Hosp, RChina, Shanghai 200032, Peoples R China;[5]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2023

卷号：5

期号：2

起止页码：1169

外文期刊名：ACS APPLIED POLYMER MATERIALS

收录：;EI(收录号：20230613539063);WOS:【SCI-EXPANDED(收录号:WOS:000963178200001)】；

基金：? ACKNOWLEDGMENTS This work was financially supported by the National key research and development program of the International scientific and technological innovation cooperation project among governments (2021YFE0100400) and Shanghai Science and Technology Innovation Action Plan integrated circuit field project (22501100500) .

语种：英文

外文关键词：nanogel; tough and sticky; temperature-responsive; dopamine methacrylamide (DMA); multi-network hydrogel

摘要：The adhesion and mechanical properties of hydrogels used for vascular wound repair often deteriorate dramatically on wet surfaces, resulting in ineffective repair. In this work, a poly(N-isopropyl acrylamide-co-dopamine methacrylamide) nanogel with dopamine groups was synthesized and introduced into a polyacrylamide (PAAm) hydrogel to produce temperature-responsive hydrogels, which greatly improved mechanical and adhesive properties of PAAm hydrogels. Nanogel-reinforced PAAm (NR-PAAm hydrogel) can adhere to the surface of various solid materials and biological tissues through special physical interactions, which exhibited different mechanical and adhesion properties as temperature changes below or above the lower critical solution temperature (LCST). The maximum adhesion of the NR-PAAm hydrogel on the aluminum surface was 78 kPa. In addition, the NR-PAAm hydrogel exhibited sufficient mechanical properties with a fracture stress of 103.6 kPa at a fracture strain of 1800%. The NR-PAAm hydrogel has good adhesion on wet surfaces and could adhere for 600 s at a pressure difference of 30 mmHg. Hence, the obtained temperature-responsive hydrogels have excellent tunable mechanical properties and adhesion properties, which provides a theoretical basis for the development of vascular repair materials in the future.