文献类型：期刊文献

英文题名：Photo-controlled targeted intracellular delivery of both nitric oxide and singlet oxygen using a fluorescence-trackable ruthenium nitrosyl functional nanoplatform

作者：Xiang, Hui-Jing[1,2];An, Lu[3,4];Tang, Wei-Wei[1,2];Yang, Shi-Ping[3,4];Liu, Jin-Gang[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2015

卷号：51

期号：13

起止页码：2555

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000349319500016)】；

基金：This study was financially supported by the NSF of China (21271072), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning, and sponsored by the Shanghai Pujiang Program (13PJ1401900).

语种：英文

摘要：A multifunctional nitric oxide (NO) delivery nanoplatform that combines functionalities of target directing, fluorescence tracking, and photo-controlled target attacking was developed. The {Ru-NO@TiO2 NPs} nanoplatform selectively targeted folate- receptor over- expressed cancer cells while being simultaneously traced based on its inherent fluorescence. Intracellular localized NO and singlet oxygen were produced on demand by controlled visible light illumination, producing a synergistic cytotoxic effect to cancer cells.