文献类型：期刊文献

英文题名：Promotional Effect of Tertiary Amine on Asymmetric Catalytic Hydrogenation of Ethyl Pyruvate Over Pt/Al₂O₃ in Acetic Acid

作者：Tao, Guozhong[1];Lu, Guanzhong[1];Guo, Yun[1];Wang, Yanqin[1];Guo, Yanglong[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Res Inst Ind Catalysis, Shanghai 200237, Peoples R China

年份：2010

卷号：22

期号：1

起止页码：461

外文期刊名：ASIAN JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000274581500063)】；

基金：The authors would like to acknowledge the financial support of the Commission of Science and Technology of Shanghai Municipality (No. 0552nm022).

语种：英文

外文关键词：Asymmetric hydrogenation; Promotional effect; Tertiary amine; Ethyl pyruvate; Cinchona alkaloid; Pt/Al2O3

摘要：In the asymmetric hydrogenation of ethyl pyruvate over cinchona alkaloid modified Pt/Al2O3 in acetic acid under atmospheric pressure, the enantioselectivity was improved and the reaction rate was accelerated upon addition of tertiary amine. The size of the alkyl substitute in tertiary amine molecule has significant impact on the improvement. Triethylamine is the most effective additive compared with tri-n-butylamine, tri-n-propylamine and trimethylamine. There is an optimum adding amount (0.4 mol/L) of all tertiary amines, at which triethylamine can increase the enantioselectivity of product from 51 to 72%. The role of tertiary amine in the promotional effect was discussed.