文献类型：期刊文献

英文题名：Synthesis of 1,2-disubstituted 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives

作者：Ma, Fei[1];Ma, Lei[1];Lei, Min[2];Hu, Lihong[2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2014

卷号：145

期号：6

起止页码：1035

外文期刊名：MONATSHEFTE FUR CHEMIE

收录：;EI(收录号：20242616516248);WOS:【SCI-EXPANDED(收录号:WOS:000337046500021)，CCR-EXPANDED(收录号:WOS:000337046500021)】；

基金：This work was supported by the National Natural Science Foundation of China (Grants 30925040, 81102329, 81273397), the Chinese National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program" (Grants 2013ZX09508104, 2012ZX09301001-001, 2011ZX09307-002-03), and the Science Foundation of Shanghai (Grant 12XD1405700).

语种：英文

外文关键词：Aldehyde; Amine; 1H-Indole-2-carboxylic acid; Mannich reaction

摘要：A facile and efficient method for the synthesis of 1,2-dihydropyrrolo[3,4-b]indol-3(4H)-one derivatives via a two-step reaction has been developed. The starting materials of 1H-indole-2-carboxylic acid, aldehyde, and amine are mixed and refluxed in ethanol to generate Mannich products, which are dehydrated in the presence of 2-(7-aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluroniumto form the desired products, 1,2-dihydropyrrolo[3,4-b] indol-3(4H)-ones.