文献类型：期刊文献

英文题名：Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases

作者：Zhang, Yu-Hui[1];Chen, Fei-Fei[1];Li, Bo-Bo[1];Zhou, Xin-Yi[1];Chen, Qi[1];Xu, Jian-He[1];Zheng, Gao-Wei[1]

机构：[1]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：22

期号：9

起止页码：3367

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000530076400013)，CCR-EXPANDED(收录号:WOS:000530076400013)】；

基金：The work was financially supported by the National Natural Science Foundation of China (Nos. 21878085, 21536004, and 21871085), the National Key Research and Development Program of China (2019YFA09005000), and the Fundamental Research Funds for the Central Universities (22221818014).

语种：英文

摘要：Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99% ee) were stereocomplementarily synthesized in good yield (60-80%), demonstrating the feasibility of IREDs for generating pharmaceutically relevant chiral 2-aryl-substituted pyrrolidine intermediates.