文献类型：期刊文献

英文题名：An in vitro investigation of the mechanical-chemical and biological properties of calcium phosphate/calcium silicate/bismutite cement for dental pulp capping

作者：Shen, Qingyi[1];Sun, Jiao[1];Wu, Jie[1];Liu, Changsheng[2];Chen, Fangping[2]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Biomat Res & Testing Ctr, Shanghai 200011, Peoples R China;[2]E China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2010

卷号：94B

期号：1

起止页码：141

外文期刊名：JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000278697400016)】；

基金：Contract grant sponsor: Shanghai Sci-Tech Committee Foundation; contract grant number: 08DZ2291600 Contract grant sponsor: Shanghai Leading Academic Discipline Project; contract grant number: S30206

语种：英文

外文关键词：pulp-capping agent; mechanical and chemical properties; calcium phosphate/calcium silicate/bismutite; cytotoxicity; antibacterial

摘要：The properties of new calcium phosphate/calcium silicate/bismutite (CPCSBi) cement were compared with those of calcium hydroxide (CH) and Dycal cements in dental pulp-capping applications. CPCSBi is composed of hydroxyapatite, tetracalcium phosphate, bismutite, and calcium silicate, which was analyzed by SEM, FTIR, and XRD. The results of ion release from CPCSBi showed that the concentrations of Bi3+, Ca2+, PO4(2-), and Si4+ increased with time in deionized water solutions. The setting time of CPCSBi and Dycal was 13 min 50 s and 2 min 25 s, respectively. There were no statistical differences in compressive strength and solubility between CPCSBi and Dycal (p > 0.05). The pH of CPCSBi (10.9) was lower than that of CH (11.6) and Dycal (12.5) after immersion for 24 h. Only slight cytotoxicity appeared for CPCSBi, whereas both CH and Dycal produced moderate discoloration and lysis. In antimicrobial tests against Sm, Av, La, and Sa, the antimicrobial potency of the CPCSBi was approximately 5-10 times greater than that of Dycal and CH groups. The dissoluble dentin matrix components (DDMCs) extracted from CPCSBi exposed to dentin powder demonstrated increased expression of dentin sialophosphoprotein (DSPP) and soteocalcin (OCN) dramatically in human pulp cells by RT-PCR. These results suggest that CPCSBi will be a good candidate for use as a dental pulp-capping agent in future. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B:141-148, 2010.