文献类型：期刊文献

英文题名：Access to spiro-bicyclo[2.1.1]hexanes via BF3Et2O-catalyzed formal [2π+2σ] cycloaddition of bicyclo[1.1.0]butanes with benzofuran-derived oxa(aza)dienes

作者：Su, Jia-Yi[1];Zhang, Jian[2];Xin, Zhi-Yun[2];Li, Hao[1];Zheng, Hanliang[2];Deng, Wei-Ping[2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Zhejiang Normal Univ, Dept Chem & Mat Sci, Key Lab Minist Educ Adv Catalysis Mat, Jinhua 321004, Peoples R China

年份：2024

卷号：11

期号：16

起止页码：4539

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001259978600001)，CCR-EXPANDED(收录号:WOS:001259978600001)】；

基金：This work was supported by the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (No. 2022R01007), the National Key Research and Development Program of China (2021YFA0804900), and the Start-up Research Grant from Zhejiang Normal University.

语种：英文

摘要：Herein, we have developed a method for the construction of spiro[benzofuran-2,2 '-bicyclo[2.1.1]hexanes] via BF3Et2O-catalyzed formal [2 pi + 2 sigma] cycloaddition of bicyclo[1.1.0]butanes with benzofuran-derived oxa(aza)dienes. This transformation allowed for facile access to a variety of functionalized spiro-bicyclo[2.1.1]hexanes in good yields (up to 99% yield) with excellent chemoselectivities and a broad substrate scope (34 examples) under mild reaction conditions. Moreover, the synthetic utility of the cycloadducts was further emphasized through a scale-up experiment and subsequent synthetic transformations.