文献类型：期刊文献

中文题名：柠檬酸溶胶-凝胶纳米MgO的分散及其抗菌性能的研究

英文题名：Study on the Dispersion and Antibacterial Activity of Nano-scaled MgO Prepared by Citric Acid Sol-gel Method

作者：张志刚[1];袁媛[1];刘昌胜[1]

机构：[1]教育部生物医用材料工程研究中心华东理工大学生物材料研究所,上海200237

年份：2006

卷号：25

期号：6

起止页码：770

中文期刊名：中国生物医学工程学报

外文期刊名：Chinese Journal of Biomedical Engineering

收录：CSTPCD;;Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：上海市纳米专项课题(0144nm064);上海市国际合作项目(035207025)。

语种：中文

中文关键词：纳米MgO;分散性;抗菌性能;最低抑制浓度(MIC);细菌总数测定法

外文关键词：nano-scaled MgO; dispersion; antibacterial activity ; MIC ; determination of the sum of bacterium

摘要：本研究采用柠檬酸溶胶-凝胶法制备了大小50nm^100nm、均匀分散的纳米氧化镁粉末。从静电稳定机制着手,采用六偏磷酸钠为分散剂对制备的纳米MgO进行分散处理,研究了六偏磷酸钠的含量、溶液pH值对分散效果的影响。在此基础上,以大肠杆菌和金黄色葡萄球菌为细菌模型,并以微米级MgO为对照,分别采用MIC法和细菌总数测定法对纳米MgO的抗菌性能进行了定性和定量研究。研究结果显示:当六偏磷酸钠用量为0.2wt%,pH=8时MgO的悬浮液稳定性较好。纳米MgO对大肠杆菌和金黄色葡萄球菌均呈现出良好的抗菌活性,而微米级MgO不具有抗菌活性。
Nano-scaled MgO with uniform particle size（50nm- 100nm）and homogeneous dispersion was synthesized by citric acid sol-gel method. Based on the mechanism of electrostatic stabilization, the prepared nano-scaled MgO powder was treated with sodium hexametaphosphate and the effects of the content of sodium hexametaphosphate and pH value on the dispersive stability of nano-scaled MgO were investigated. The antibacterial activity of nano-scaled MgO on the es cherichiacoli and staphylcececusau reus was qualitative and quantitative investigated by Minimum Inhibitoty Concentration（MIC） method and Calculate the Sum of Bacterium, using micro-scaled MgO powders as control. The results showed that the optimum dispersive condition was sodium hexametaphosphate 0.2wt%, pH = 8. Nano-scaled MgO exhibited antibacterial activity. But the micro-scaled MgO is out of antibacterial activity.