文献类型：期刊文献

英文题名：Microencapsulation improves the effects of octacosanol to ameliorate alcoholic liver injury

作者：Meng, Xiangchun[1];Sun, Yishu[1];Xu, Tao[2];Tang, Lihua[3];Chang, Yaning[1];Zhou, Yingjun[1]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Huzhou Shengtao Biotechnol LLC, Huzhou, Zhejiang, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem Engn, Shanghai, Peoples R China

年份：2024

卷号：3

期号：2

起止页码：172

外文期刊名：FOOD BIOENGINEERING

收录：EI(收录号：20242416253404);WOS:【ESCI(收录号:WOS:001328268300006)】；

语种：英文

外文关键词：alcoholic liver injury; food processing; konjac glucomannan; microcapsules; octacosanol

摘要：Octacosanol is a plant natural product with the potential to ameliorate alcoholic liver injury. However, its poor solubility limits its application in the food industry. This study first verified that octacosanol has a favorable effect on acute and subchronic alcoholic liver injury in mice by protecting the gastric mucosa and ameliorating disease levels. Additionally, octacosanol microcapsules were prepared under the optimal drying conditions of the feed flow rate of 400 mL/h and drying temperature of 180 degrees C to improve the ameliorative effects of octacosanol, with moisture content, water activity, dispersibility, and solubility of 1.53%, 0.16%, 89.84%, and 95.30%, respectively. The microcapsules had a spherical structure, and the droplet sizes after redissolution ranged from 0.061 to 4.63 mu m. Instrumental measurements and simulated digestion experiments have shown that microencapsulation enhanced the solubility and thermal stability of octacosanol, with 90.88% of the octacosanol being continuously released. As expected, microencapsulation significantly enhanced the effect of octacosanol in ameliorating alcoholic liver injury by determining the disease index in the mice model. This study demonstrated the beneficial effects of octacosanol on alcoholic liver injury and explored a viable method to improve its solubility and bioaccessibility, thereby enhancing its therapeutic efficacy for the treatment of alcoholic liver injury. Octacosanol ameliorated acute and chronic alcoholic liver injury. Spray drying prepared Octacosanol microcapsules with excellent physicochemical properties. Microencapsulation improved the ability of Octacosanol to ameliorate alcoholic liver injury. image