文献类型：期刊文献

英文题名：Comparative studies on the enantioselective fluorination of oxindoles with structurally modified N-fluorobenzenesulfonimides

作者：Zhang, Yan[1,2];Yang, Xian-Jin[1,2,3,4];Xie, Tian[4];Chen, Guan-Long[1,2];Zhu, Wen-Hua[1,2];Zhang, Xiao-Qi[2];Yang, Xue-Yan[1,2];Wu, Xin-Yan[1,2];He, Xiao-Peng[1,2];He, Hao-Ming[4]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China;[4]Wengfu Grp Co Ltd, Guizhou 550000, Peoples R China

年份：2013

卷号：69

期号：24

起止页码：4933

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000319247000013)】；

基金：We thank the financial support by Guizhou Wengfu Group Co. Ltd.

语种：英文

外文关键词：N-Fluorobenzenesulfonimides; Enantioselectivity; Fluorination; Oxindole

摘要：Structurally modified N-fluorobenzenesulfonimides (NFSIs) have been used to study the enantioselective fluorination of oxindoles in the presence of a bis-cinchona alkaloid, (DHQD)(2)PHAL, as the catalyst. We observe that the NFSI analogues bearing two tert-butyl groups at the para-position of the symmetric phenyl rings led to an enhanced enantioselectivity in most cases (up to 96% ee) compared with the unmodified NESIs (less than 69% ee). (C) 2013 Elsevier Ltd. All rights reserved.