文献类型：期刊文献

英文题名：Palladium-Catalyzed Diverse mono-Acyloxylation of 5-Alkyl-4-aryl-thiazole-2-carboxylates

作者：Yu, Kun-Kun[1];Guo, Ying[1];Hu, Ya-Hua[1];Xu, Zhi[1];Liu, Hong-Wei[1];Liao, Dao-Hua[1];Ji, Ya-Fei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2016

卷号：5

期号：10

起止页码：1219

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000387750400006)，CCR-EXPANDED(收录号:WOS:000387750400006)】；

基金：We gratefully thank the National Natural Science Foundation of China (project nos. 21176074 and 21476074) and the Research Fund for the Doctoral Program of Higher Education of China (project no. 20130074110009) for financial support.

语种：英文

外文关键词：acetoxylation; acyloxylation; C-H activation; palladium; thiazoles

摘要：The palladium-catalyzed oxidative acyloxylation of 5-alkyl-4-aryl-thiazole-2-carboxylates via a direct ortho-Csp(2)-H bond activation has been described with a newly reported radical mechanism. Based on the late-stage functionalization of the highly substituted thiazoles, the reaction delivered multifarious valuable acyloxylated products with moderate-to-excellent yields. The transformation affords highly functionalized substrates, has broad scope of carboxylic acid coupling partners, excellent site-selectivity, rapid reaction rates, simple operation and mild conditions. The diverse acyloxylation reaction allows rapid access to a plethora of mono-acyloxylated products from the functionalized thiazoles.