文献类型：期刊文献

英文题名：Nonenzymatic kinetic resolution of α-aryl substituted allylic alcohols catalyzed by acyl transfer catalyst Np-PIQ

作者：Jiang, Shan-Shan[1];Gu, Bo-Qi[1];Zhu, Ming-Yu[1];Yu, Xingxin[1];Deng, Wei-Ping[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China

年份：2015

卷号：71

期号：8

起止页码：1187

外文期刊名：TETRAHEDRON

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000350919200004)，CCR-EXPANDED(收录号:WOS:000350919200004)】；

基金：This work was supported by the Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (No. 21372074).

语种：英文

外文关键词：Kinetic resolution; Allylic alcohols; Nucleophilic catalyst

摘要：Chiral alpha-aryl substituted allylic alcohols are important versatile synthetic intermediates. We report here an effective nonenzymatic kinetic resolution of racemic alpha-aryl substituted allylic alcohols by introducing different aryl groups with acyl transfer catalyst Np-PIQ and propionic anhydride, providing moderate to good selectivity factors (S=12-37). (C) 2015 Elsevier Ltd. All rights reserved.