文献类型：期刊文献

中文题名：A novel snail-inspired bionic design of titanium with strontium-substituted hydroxyapatite coating for promoting osseointegration

作者：Zhen Geng[1,3];Xueping Li[2];Luli Ji[1,3];Zhaoyang Li[2];Zhenduo Cui[2];Jing Wang[1,4];Jingyuan Cui[1];Xianjin Yang[2];Changsheng Liu[1,3,5]

机构：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology,Shanghai,200237,China;[2]Tianjin Key Laboratory of Composite and Functional Materials,School of Materials Science and Engineering,Tianjin University,Tianjin,300350,China;[3]Engineering Research Center for Biomedical Materials of the Ministry of Education,East China University of Science and Technology,Shanghai,200237,China;[4]The State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai,200237,China;[5]Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai,200237,China

年份：2021

期号：20

起止页码：35

中文期刊名：Journal of Materials Science & Technology

外文期刊名：材料科学技术（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；PubMed;

基金：This work was financially supported by National Natural Science Foundation of China for Innovative Research Groups(Grant No.51621002);the China Postdoctoral Science Foundation(Grant No.2018M640350).

语种：英文

中文关键词：Bionic structure;Bioactive apatite;Osteoclast activity;Osseointegration;Bone-implant bonding strength

摘要：As the population ages,more and more people are suffering from osteoarthritis(OA),resulting in an increasing requirement for joint implants.Surface modification to improve the topology and composition of the implants has been proved to be an effective way to improve the primary stability and long-term success rate of joint implants.In this work,a bionic micro/nano-structure accompanied with a strontium-substituted hydroxyapatite(SrHA)coating was fabricated on titanium(Ti)surface via electrochemical corrosion,ultrasonic treatment,and hydrothermal deposition methods.Thein vitro study demonstrated that the bionic structure and the bioactive apatite could synergistically increase the expressions of integrin-related gene(ITGα5β1)and osteoblastic genes(Col-I and OCN),and thus promote osteoblast growth.In addition,owing to the anti-bone resorption property of Sr^(2+),the coating could effectively inhibit osteoclast differentiation and proliferation.In a word,the prepared samples not only promoted osteogenesis but also inhibited osteoclastogenesis.The in vivo experiment via a rabbit model found that the bionic structured surface provided the pore for new bone ingrowth,which was beneficial to the mechanical interlocking between the implant and bone.Moreover,the bionic structure and bioactive SrHA coating had a synergistic effect on promoting bone formation,osseointegration,and bone-implant bonding strength.This study therefore presented a new strategy to fabricate bio-functionalized Ti-based implants for potential application in orthopedics field.