文献类型：期刊文献

英文题名：Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections

作者：Qian, Yuxin[1];Deng, Shuai[2];Lu, Ziyi[2];She, Yunrui[2];Xie, Jiayang[2];Cong, Zihao[2];Zhang, Wenjing[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Specially Funct Polymer Mat & Related Tec, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：4

期号：5

起止页码：3811

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20204409436399);WOS:【ESCI(收录号:WOS:000653545300010)】；

基金：This work was supported by the Natural Science Foundation of Shanghai (18ZR1410300), the National Natural Science Foundation of China (21861162010, 21774031, and 31800801), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), the National Key Research and Development Program of China (2016YFC1100401), the Research Program of the State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (22221818014 and 50321041917001).

语种：英文

外文关键词：host defense peptide (HDP); HDP-mimicking polymer; antimicrobial surfaces; antimicrobial mechanism; subcutaneous implant infection model

摘要：Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce drug resistance, and remarkable biocompatibility. In this review, covalent-grafting strategies are mainly discussed to tether host defense peptide mimicking polymers on surfaces, aiming to obtain potent antimicrobial activity. In addition to the antimicrobial function, we review the antimicrobial mechanism of these polymer-modified antimicrobial surfaces in precedent literatures. We also review the in vivo subcutaneous implant infection models that are critical assessments for potential biomedical applications. In the end, we provide our perspective on the future development of this field, especially for biomedical applications.