文献类型：期刊文献

中文题名：松质骨粒型自固化磷酸钙人工骨初步临床应用

英文题名：PRELIMINARY CLINICAL APPLICATION OF CANCELLOUS GRANULE-TYPE CALCIUM PHOSPHATE CEMENT

作者：阿不来提.阿不拉[1];艾克拜尔.艾拜也都拉[2];艾合买提江.玉素甫[1];刘昌盛[3];黄河清[3]

机构：[1]新疆医科大学第一附属医院骨科中心显微修复外科,乌鲁木齐830054;[2]新疆医科大学附属中医医院脊柱二科;[3]华东理工大学教育部医用生物材料工程研究中心

年份：2010

卷号：24

期号：9

起止页码：1100

中文期刊名：中国修复重建外科杂志

外文期刊名：Chinese Journal of Reparative and Reconstructive Surgery

收录：CSTPCD;;Scopus;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；PubMed;

语种：中文

中文关键词：松质骨粒型自固化磷酸钙人工骨;骨缺损;修复

外文关键词：Cancellous granule-type calcium phosphate cement Bone defect Repair

摘要：目的初步探讨松质骨粒型自固化磷酸钙人工骨临床应用疗效。方法随机选择2008年7月-2009年7月收治的35例42处四肢骨折、骨不连、良性骨肿瘤患者。男32例,女3例;年龄9～73岁,中位年龄41岁。骨折19例24处,骨折术后骨不连3例3处,尺、桡骨截骨矫形2例4处,股骨粗隆骨囊肿2例2处,内生软骨瘤3例3处,髂骨供骨区骨缺损5例5处,腰椎管狭窄植骨融合术(椎间植骨)1例1处。骨缺损大小1～5cm。于骨缺损处植入1～5g人工骨修复缺损。结果术后35例均获随访,随访时间8～23个月,平均13.7个月。32例39处切口Ⅰ期愈合,于术后10～14d拆线;2例2处切口裂开,行再次清创取出人工骨后切口愈合;1例1处切口出现渗出,经对症处理后切口愈合。人工骨植入局部无皮肤红肿、皮温增高、出现斑丘疹或皮肤溃破等不良反应。术后6个月X线片示人工骨与骨组织融合,骨缺损基本修复;12个月时骨缺损修复,人工骨被完全吸收。结论松质骨粒型自固化磷酸钙人工骨作为新一代骨移植材料,适用于创伤骨折整复后遗留骨缺损的填充植骨、良性骨肿瘤或肿瘤样病变病灶清除术后的骨缺损、髂骨供骨区的骨缺损及矫形植骨等。
Objective To investigate the clinical efficacy of the cancellous granule-type calcium phosphate cement in repair bone defect. Methods Between July 2008 and July 2009, 35 patients （42 limbs） with fractures, nonunion, and benign bone tumor were treated with cancellous granule-type calcium phosphate cement. There were 32 males and 3 females, with an age range from 9 to 73 years （median, 41 years）, including 24 limb fractures （19 cases）, 4 osteotomy for deformity of ulna and radius （2 cases）, 2 femur intertrochanteric bony cysts （2 cases）, 3 enchondroma （3 cases）, 5 bone defect at donor ilium （5 cases）, 3 nonunion （3 cases）, and 1 lumbar spinal stenosis （1 case）. The size of bone defect was 1-5 cm. Bone defect was repaired with cancellous granule-type calcium phosphate cement （1-5 g）. Results All cases were followed up 8-23 months （13.7 months on average）. Thirty-nine incisions （32 cases） healed by first intention and the suture was removed after 10-14 days. Incision dehiscence occurred in 2 cases, and wounds healed after second debridement and removal of artificial bone. Exudation of incision occurred in 1 case, and wound healed after symptomatic treatment. No local red swelling, higher temperature, maculopapule, and ulceration of skin occurred at implantation site. X-ray films showed that bone graft fusion was achieved and bone defect was radically repaired at 6 months after operation and artificial bone was absorbed completely at 12 months. Conclusion Cancellous granule-type calcium phosphate cement can be used as a new graft bone material, which is suitable for defect filling after traumatic fracture, benign bone tumors, and iliac bone donor.