文献类型：期刊文献

英文题名：Insights of Human Exposure and Dermal Uptake to Per- and Polyfluoroalkyl Substances from Domestic Cosmetics and Personal Care Products in China

作者：Zhao, Xuan[1]; Fu, Mengru[1]; Yang, Yuhe[1]; Chen, Anqi[1]; Han, Yanna[1]; Gong, Kailin[1]; Xu, Xiang[1]; Xie, Wenwen[1]; Zhang, Wei[1]; Peng, Cheng[1]; Zhou, Bingsheng[3]; Fu, Rongbing[2]

机构：[1] State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] College of Environmental Science and Engineering, Tongji University, Shanghai, 200092, China; [3] Shanghai Academy of Environmental Sciences, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240057476)

语种：英文

外文关键词：Propionic acid

摘要：Per- and polyfluoroalkyl substances (PFASs) are synthetic chemicals reported in daily supplies, and skin absorption is one of the routes for human exposure to PFASs. This study aims to evaluate the potential risks of PFASs exposure to humans from cosmetics and personal care products. Initially, a random sampling of 44 domestic cosmetics and personal care products was conducted to investigate the concentrations of 24 PFASs. PFASs concentrations were lower than 100 ng/g in 86.4% of products, and PFCAs and PAPs were dominant. Notably, the presence of perfluoropropoxy propanoic acid (Gen X, the alternative of PFOA) was noteworthy. Furthermore, in vitro skin absorption experiments were performed using excised porcine skin to predict the skin absorption of PFASs to human, and the absorption rates of the measured 6 PFASs ranged from 29.5%~82.8%. Finally, on the basis of the above experimental results and creatively determining the skin absorption rates of PFASs separately based on the Lipinski’s rule of 5, the daily exposure dose (DED) of ∑PFASs from skin exposure through cosmetics and personal care products was evaluated to be 2.17 ng/kg-bw/day. Conclusively, this study emphasizes that cosmetics and personal care products are important sources leading to the PFASs skin exposure. ? 2024, The Authors. All rights reserved.