文献类型：期刊文献

中文题名：Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold

英文题名：Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold

作者：Yin-Bo Chen[1];Ji-Ling Li[1];Xu-Sheng Shao[1];Xiao-Yong Xu[1];Zhong Li[1]

机构：[1]Shanghai Key Lab of Chemistry Biology,School of Pharmacy,East China University of Science and Technology

年份：2013

卷号：24

期号：8

起止页码：673

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2013_2014】；PubMed;

基金：supported by National Basic Research Program of China(973 Program,No.2010CB126100);National High Technology Research and Development Program of China (863 Program,No.2011AA10A207);supported by National Key Technology R&D Program of China(No. 2011BAE06B01)

语种：英文

中文关键词：Anthranilic diamides Benzyl sulfide Synthesis Insecticidal activity

外文关键词：Anthranilic diamides Benzyl sulfide Synthesis Insecticidal activity

摘要：A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~1H NMR,^（13）C NMR,^（19）F NMR and HRMS.The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm（Mythimna sepatara） at the concentration of 500 mg/L,Exhilaratingly,the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L.The difference in activities between the target compounds was influenced by the substituents,which provided some hints for further investigation on structure modifications.
A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~1H NMR,^（13）C NMR,^（19）F NMR and HRMS.The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm（Mythimna sepatara） at the concentration of 500 mg/L,Exhilaratingly,the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L.The difference in activities between the target compounds was influenced by the substituents,which provided some hints for further investigation on structure modifications.