文献类型：期刊文献

英文题名：Structural design and antimicrobial properties of polypeptides and saccharide-polypeptide conjugates

作者：Wu, Yueming[1];Xia, Guixue[2];Zhang, Weiwei[2];Chen, Kang[2];Bi, Yufang[2];Liu, Shiqi[2];Zhang, Wenjing[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Specially Funct Polymer Mat & Related Tec, Frontiers Sci Ctr Mat & Dynam Chem, Minist Educ,Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2020

卷号：8

期号：40

起止页码：9173

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20204409440549);WOS:【SCI-EXPANDED(收录号:WOS:000580584800001)】；

基金：This research was supported by the Natural Science Foundation of Shanghai (18ZR1410300), the National Natural Science Foundation of China (No. 21861162010, 21774031, 31800801), Program of Shanghai Academic/Technology Research Leader (20XD1421400), the National Key Research and Development Program of China (2016YFC1100401), Research program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities (No. 22221818014, 50321041917001).

语种：英文

外文关键词：Network security - Structural design - Biocompatibility - Losses - Microorganisms - Polypeptides

摘要：The problems of microbial infections and the emergence of drug-resistant microbes are increasingly serious, causing countless loss of lives and economic loss. The discovery and study of host defense peptides opened a new avenue in developing antimicrobial regents, and have attracted a lot of attention in recent years. Compared with natural host defense peptides, synthetic antimicrobial polypeptides can be conveniently synthesized in large scale and with low cost. Furthermore, saccharide-polypeptide conjugates have been valued for their optimal effect on antimicrobial properties and biocompatibility. In this review article, we provide an overview of the development and progress of antimicrobial polypeptides and saccharide-polypeptide conjugates regarding their structural design, biological functions and antimicrobial mechanism. By pointing out the challenges, we also provide future prospects of this research field from our perspectives.