文献类型：期刊文献

英文题名：Novel 2′-hydroxylfurylchalcones: synthesis and biological activity

作者：Deng, Yunfei[1];He, Yuan[1];Zhan, Taisong[1];Huang, Qingchun[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2010

卷号：345

期号：13

起止页码：1872

外文期刊名：CARBOHYDRATE RESEARCH

收录：;EI(收录号：20103413184839);WOS:【SCI-EXPANDED(收录号:WOS:000281998300008)】；

基金：This work was supported by the National Key Project for Basic Research (2010CB126101), the Shanghai Foundation of Science and Technology (073919107) and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：2 '-Hydroxylfurylchalcone; Herbicides; Antifungal activity

摘要：Twelve novel 2'-hydroxylfurylchalcones have been synthesized by Claisen-Schmidt condensation with galactosylisomaltol, a reagent prepared from lactose. The procedures are environmentally benign and economical. All the compounds are identified by IR, (1)H NMR and (13)C NMR spectroscopy and by mass spectrometry. Preliminary bioassays indicate that all the title compounds show moderately high herbicidal activities against the height and/or the fresh weight of the seedlings of cucumber, rape, amaranth, wheat, sorghum and Chinese sprangletop at 7.5 g of active ingredient per hm(2). However, the compounds exhibit weak fungicidal activities against cucumber powdery mildew, and no activities against rice blast, cucumber grey mould and cucumber downy mildew. The structure-activity relationships are discussed. The present work demonstrates that 2'-hydroxylfurylchalcones could be used as potential lead compounds for further study of novel herbicides. (C) 2010 Elsevier Ltd. All rights reserved.