文献类型：期刊文献

英文题名：Fabrication and properties of porous scaffold of magnesium phosphate/polycaprolactone biocomposite for bone tissue engineering

作者：Wu, Fan[1];Liu, Changsheng[2,3];O'Neill, Brian[1];Wei, Jie[2,3];Ngothai, Yung[1]

机构：[1]Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Shanghai 200237, Peoples R China

年份：2012

卷号：258

期号：19

起止页码：7589

外文期刊名：APPLIED SURFACE SCIENCE

收录：;EI(收录号：20122215063671);WOS:【SCI-EXPANDED(收录号:WOS:000304254000058)】；

基金：The authors are indebted to the financial supports from Program for Changjiang Scholars and Innovative Research Team in University (IRT0825) and Shanghai Science and Technology commission (No. 09410709100 and 10540709800).

语种：英文

外文关键词：PCL; Magnesium phosphate; Porous scaffold; Degradation

摘要：In this study, porous scaffolds made of magnesium phosphate (MP)/polycaprolactone (PCL) biocomposite were developed for bone tissue engineering applications. The composite scaffolds were fabricated by the particulate leaching method using sodium chloride particles as porogen. The obtained scaffold with porosity around 73% presents a porous structure with interconnected open pores. Hydrophilicity of the scaffolds was enhanced by the incorporation of MP component as demonstrated by the water contact angle measurement. The results of the in vitro degradation study show that the MP/PCL composite scaffolds degraded faster than PCL scaffolds in phosphate buffered saline (PBS). In addition, the degradation rate of the scaffolds could be tuned by adjusting the content of MP component in the composite. The results indicate that the MP/PCL composite scaffold has a potential application in bone tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.