文献类型：期刊文献

英文题名：Asymmetric dearomatization enabled by chiral Br?nsted acid activation of ynamides

作者：Li, Xingguang[1,2]; Sun, Jianwei[1]

机构：[1] Department of Chemistry, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong; [2] Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, State Key Laboratory of Chemical Engineering, School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai, 200237, China

年份：2022

卷号：65

期号：1

起止页码：3

外文期刊名：Science China Chemistry

收录：EI(收录号：20214811233390)

语种：英文

外文关键词：Naphthol

摘要：Chiral Br?nsted acid catalysis has evolved into a powerful synthetic tool in asymmetric synthesis. Researchers have conducted studies to demonstrate that Asymmetric dearomatization enabled by chiral Br?nsted acid activation of ynamides. The researchers reported their progress in addressing the above challenge by activation of ynamide C≡C bonds with a chiral phosphoric acid, enabling intramolecular asymmetric dearomatization of naphthols, phenols and pyrroles for the rapid assembly of diverse valuable spirocyclic structures with high efficiency and enantioselectivity. The key to success is the formation of a keteniminium ion, which has electrostatic interaction with the chiral phosphate ion.