文献类型：期刊文献

英文题名：Exosome-liposome hybrid system with antioxidant and anti-inflammatory activities targeting glial cells for the treatment of central nervous system diseases

作者：Chen, Yutong[1];Guo, Shuting[1];Fan, Mingrui[1];Yang, Songlin[1];Lin, Qiuxia[1];Zou, Jiafeng[1];Xu, Junyuan[1];Zheng, Tongtong[1];He, Kangtai[1];Gao, Feng[1,2,3];Chen, Yanzuo[1,2]

机构：[1]East China Univ Sci & Technol, Pharmaceut Engn & Proc Chem Engn Res Ctr, Sch Pharm, Shanghai Key Lab New Drug Design,Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Optogenet & Synthet Biol Interdisciplinary Res Ctr, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2026

卷号：37

期号：9

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001808100800001)】；

基金：This work was supported by Development Program of China (No. 2019YFA0904800) , Shanghai Frontiers Science Cen-ter of Optogenetic Techniques for Cell Metabolism, Science and Technology Commission of Shanghai Municipality (No. 10DZ2220500) , Shanghai Committee of Science and Technology (No. 11DZ2260600) .

语种：英文

外文关键词：Central nervous system disease; Glial cells; Exosome-liposome hybrid system; Fisetin; Pioglitazone

摘要：Central nervous system diseases (CNSDs), such as Parkinson's disease (PD) and depression, have attracted considerable attention due to their high morbidity and mortality rates. Neuronal damage in CNSDs is primarily driven by inflammation and oxidative stress induced by activated astrocytes and microglia. Thus, new therapeutic strategies are urgently needed that not only enable effective drug delivery across the blood-brain barrier (BBB), but also specifically target lesions while exerting antioxidant and antiinflammatory effects on glial cells. To address this challenge, we developed an exosome-liposome hybrid system targeting glial cells co-loaded with fisetin (FIS) and pioglitazone (PIO) (RMP7-EL-FIS-PIO). This hybrid system crosses the BBB through the B2 bradykinin receptor-mediated opening and takes advantage of the homing properties of exosomes to accumulate at the site of brain lesions in murine models of PD and of depression. Through receptor-ligand binding and phagocytosis, the hybrid system targets glial cells to deliver drugs that inhibit their activation, thus protecting neurons. Our study demonstrates the great potential of the developed exosome-liposome hybrid system for the targeted treatment of CNSDs. (c) 2026 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.