文献类型：期刊文献

英文题名：Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini-review

作者：Li, Ke[1,2];Mohammed, Monier Alhadi Abdelrahman[1,2];Zhou, Yongshan[1,2];Tu, Hongyi[1,2];Zhang, Jiachen[1,2];Liu, Chunli[1,2];Chen, Zhenbin[1,2];Burns, Robert[3];Hu, Dongdong[4];Ruso, Juan M.[5];Tang, Zhenghua[6,7];Liu, Zhen[3]

机构：[1]Lanzhou Univ Technol, State Key Lab Gansu Adv Nonferrous Met Mat, Lanzhou, Peoples R China;[2]Lanzhou Univ Technol, Sch Mat Sci & Engn, Lanzhou, Peoples R China;[3]Frostburg State Univ, Dept Phys & Engn, Frostburg, MD 21532 USA;[4]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai, Peoples R China;[5]Univ Santiago de Compostela, Dept Appl Phys, Soft Matter & Mol Biophys Grp, Santiago De Compostela, Spain;[6]South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Guangzhou Key Lab Surface Chem Energy Mat, New Energy Res Inst,Sch Environm & Energy, Guangzhou, Peoples R China;[7]South China Univ Technol, Guangzhou Higher Educ Mega Ctr, Sch Environm & Energy, Guangdong Engn & Technol Res Ctr Surface Chem Ene, Guangzhou, Peoples R China

年份：2020

卷号：31

期号：3

起止页码：368

外文期刊名：POLYMERS FOR ADVANCED TECHNOLOGIES

收录：;EI(收录号：20194607686042);WOS:【SCI-EXPANDED(收录号:WOS:000514861200002)】；

语种：英文

外文关键词：carrier; immobilization; penicillin G acylase; reaction; reactor

摘要：Immobilized penicillin G acylase (PGA) as an important industrial catalyst can catalyze penicillin G potassium (PG) to 6-aminopenicillanic acid (6-APA). 6-APA is an important intermediate for semisynthetic penicillin drugs, which occupies a huge market space in the anti-inflammatory field; as a result, immobilized PGA occupies a huge market space in the pharmaceutical field. However, at present, there are different degrees of defects in the preparation and production process of immobilized PGAs on the market because of the huge demand; therefore, the performance of immobilized PGA and its productivity will bring huge economic benefits to enterprises. Therefore, research on immobilized PGA has always been a focus. This review first introduces the source, classification, structure, and catalytic mechanism of PGA and then studies the development of immobilization methods, immobilized carriers, reaction media, enzyme activity regeneration, and reactors of immobilized PGA in recent years.