文献类型：期刊文献

英文题名：A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

作者：Xiang, Hui-Jing[1,2];Guo, Min[1,2];An, Lu[3,4];Yang, Shi-Ping[3,4];Zhang, Qian-Ling[5];Liu, Jin-Gang[1,2]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China;[5]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China

年份：2016

卷号：4

期号：27

起止页码：4667

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20162902599844);WOS:【SCI-EXPANDED(收录号:WOS:000379491000006)】；

基金：This study was financially supported by the NSF of China (no. 21271072 and 21571062 to JGL; 21471101 to QLZ), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, the Shanghai Pujiang Program (no. 13J1401900) to JGL, and the Shenzhen Government's Plan of Science and Technology (JCY20150324140036843) to QLZ.

语种：英文

外文关键词：Cancer cells - Diseases - Cells - Cell culture - Infrared devices

摘要：Nitric oxide (NO) plays important roles in various physiological and pathological processes. The development of multifunctional nanoplatforms that enable site-specific delivery of NO is expected to provide new insights toward the realization of NO-mediated therapy. We report herein a novel nanoplatform {Lyso-Ru-NO@ FA@CDs}, (1), where a lysosome-targeting NO donor, Lyso-Ru-NO, and a folic-acid (FA)-directing group were incorporated into carbon dots (CDs). Nanoplatform 1 exhibited immediate NO release and a rapid temperature increase when irradiated using an 808 nm laser. This nanoplatform was capable of targeting folate-receptor-positive cancer cell lines and specifically accumulated in the subcellular lysosomal organelle. The dual-targeted nanoplatform 1 exhibited high cytotoxicity toward cancer cells under irradiation with 808 nm light, demonstrating substantially enhanced efficacy compared with its nontargeted counterparts. NIR-light-controlled spatiotemporal delivery of NO to targeted sites accompanied by photothermal therapy offers new possibilities for NO-involved multimodal cancer treatment.