文献类型：期刊文献

中文题名：苯酚和乙醛酸合成对羟基苯乙酸的研究(上)——缩合反应过程

英文题名：Study on Synthesis of 4 - Hydroxyphenylacetic Acid by a Condensation of Phenol with Glyoxylic Acid (I).

作者：潘鹤林[1];田恒水[1];徐志珍[1];李峰[1]

机构：[1]华东理工大学化学工程系,上海200237

年份：1998

卷号：23

期号：1

起止页码：31

中文期刊名：上海化工

外文期刊名：Shanghai Chemical Industry

语种：中文

中文关键词：苯酚;乙醛酸;缩合反应;对羟基苯乙酸

外文关键词：Phenol; Glyoxylic acid; Condensation; 4 - Hy droxy mandelic acid; 4 - Hydroxyphenyl acetic acid.

摘要：以苯酚和乙醛酸为原料,对对羟基苯乙酸制备中的缩合反应过程进行了研究.结果表明:碱液以和乙醛酸分开同时滴加为好;反应适宜温度为50℃;乙醛酸和苯酚的适宜摩尔比为1:1.5;搅拌速率在1600～2000转/分之间较好;反应时间以9～10小时为宜.
Condensation reaction of phenol with glyoxylic acid in the preparation of 4 - hydroxyphenyl acetic acid has been investigated. The condensation conditions of phenol with glyoxylic acid have been determined. The alkaline solution and aqueous glyoxylic acid are dropped slowly respectively.The condensation reaction temperature is at 5O℃.the mole ratio of glyoxylic acid to phenol is 1: 1.5, the speed of agitation is between 1600 to 2000 rpm, and the condensation reaction period is between 9 and 10 hours.