文献类型：期刊文献

英文题名：Starch-based shape memory sponge for rapid hemostasis in penetrating wounds

作者：Huang, Zhenhua[2];Wu, Juan[2];Zhao, Yujiao[2];Zhang, Dong[2];Tong, Laiqiang[2];Gao, Fan[2];Liu, Changsheng[1,2];Chen, Fangping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2023

卷号：11

期号：4

起止页码：852

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000906499600001)】；

基金：This investigation was supported by the National Natural Science Foundation of China (No. 51772100; 32171342), the Shanghai Science and Technology Agriculture Project (No. 202002080002F01474), the Shanghai Pujiang Program (16PJD015) and the Joint Fund for Equipment Preresearch of the Ministry of Education (6141A02022618).

语种：英文

摘要：Death caused by excessive blood loss has always been a global concern. Timely control of bleeding in incompressible penetrated wounds remains a great challenge. Here, we developed a shape memory sponge (SQG) based on modified starch and gelatin (Gel) to control the hemorrhage of penetrating wounds. The porous structure of SQG greatly enhanced the absorption of blood, and the adhesion of erythrocytes and platelets. The water absorption rate of SQG reached 1178.72 +/- 12.18% in 10 s. SQG quickly recovered its shape in water (similar to 3 s) and exhibited high mechanical strength (similar to 38 kPa), acting as a physically packed barrier to facilitate hemostasis. Furthermore, the positively charged sponges were conducive to activating platelets and promoting the release of coagulation factors. SQG sponges possessed the lowest blood coagulation index (BCI) of 21.32 +/- 0.19%, and presented good biocompatibility and obvious inhibitory effect on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Moreover, SQG sponges controlled complete bleeding in 69 +/- 20 s and a bleeding loss of 334 +/- 138 mg was observed, nearly 50% lower than that of gelatin sponge in rabbit liver penetrating wounds. Overall, SQG possesses a combination of potent shape recovery, rapid hemostasis, and excellent antibacterial and degradation ability, enabling promising applications for hemostasis in non-compressible penetrating wounds.