文献类型：期刊文献

英文题名：Design and Synthesis of Structural Analogues of β-Phellandrene to Attract the Yellow Peach Moth (Conogethes punctiferalis)

作者：Xu, Qian[1];Zhou, Jun-Xiang[1];Liu, Jie[1];Jiang, Tong-Li[1];Li, Zhong[1];Wan, Nian-Feng[1];Yang, Wu-Lin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2025

卷号：73

期号：43

起止页码：27388

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20254419420980);WOS:【SCI-EXPANDED(收录号:WOS:001595291000001)】；

基金：This work was supported by the Shanghai Agriculture Applied Technology Development Program, China (No. 2023-02-08-00-12-F04586) and the National Natural Science Foundation of China (No. 32172484).

语种：英文

外文关键词：attractantvalue; beta-phellandrene; Conogethespunctiferalis; insect attractant; plantvolatiles

摘要：Using plant-released volatiles to attract and control pest moths is a key approach to pest management strategies. beta-Phellandrene (beta-Phe) has been proven to be attractive to the yellow peach moth (Conogethes punctiferalis). Herein, we designed and synthesized 25 structural analogues of beta-Phe and identified four compounds (3a, 3d, 4a, and 4g) with high attraction activity. Among them, the ester-containing compound 4g exhibited the highest attraction rate (76.6%) at a concentration of 10 mg/mL, whose stability and accessibility are both superior to beta-Phe. Molecular docking results revealed that the target compounds strongly bound to the general odorant-binding protein 1 (GOBP1) of C. punctiferalis via hydrophobic interactions and pi-pi stacking. Quantum calculations demonstrated that ester groups optimize the electrostatic potential and introduce hydrogen-bonding sites. These findings elucidate structure-activity relationships and molecular recognition mechanisms of volatile attractants, offering insights for eco-friendly pest management strategies.