文献类型：期刊文献

英文题名：NIR-Triggered Multifunctional and Degradable Nanoplatform Based on an ROS-Sensitive Block Copolymer for Imaging-Guided Chemo-Phototherapy

作者：Wang, Chao[1];Huang, Baoxuan[1];Yang, Guoliang[1];Ouyang, Yingjie[1];Tian, Jia[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：20

期号：11

起止页码：4218

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20194407606543);WOS:【SCI-EXPANDED(收录号:WOS:000496343800018)】；

基金：This work was financially supported by the National Natural Science Foundation of China (51803058, 21875063) and the Fundamental Research Funds for the Central Universities (222201814018, 50321101917022).

语种：英文

外文关键词：Biodegradation - Infrared devices - Controlled drug delivery - Mammals - Block copolymers - Photosensitizers - Targeted drug delivery - Micelles

摘要：Imaging-guided chemo-phototherapy based on multifunctional nanocarriers has emerged as a promising and high-efficient cancer treatment because of the inevitable limitations of single therapy. Herein, a near-infrared (NIR) light-activated degradable polymeric nanoplatform was fabricated for chemo-phototherapy. An NIR photosensitizer, IR780, and a chemotherapeutic drug, doxorubicin (DOX), were efficiently coloaded within a reactive oxygen species (ROS)-sensitive polymeric micelle based on an amphiphilic copolymer with degradable thioketal (TK) linkages. The obtained spherical nanoparticles (denoted as (IR780/DOX)@PTK) exhibited a notable photodynamic and photothermal effect upon NIR light exposure. Furthermore, due to the rapid cleavage of TK linkers induced by ROS generated from NIR-activated IR780, (IR780/DOX)@PTK also showed an NIR light-induced degradable feature, which can be used for light-triggered tumor-specific drug release and lead to ignorable systematic toxicity after biodegradation and drug delivery. Under the guidance of NIR fluorescence and photothermal dual modal imaging, (IR780/DOX)@PTK exhibited excellent tumor accumulation after intravenously injection into 4T1-tumor-bearing mice. As verified in both in vitro and in vivo study, (IR780/DOX)@PTK presented a significant tumor suppression effect by synergistic chemo-phototherapy.