文献类型：期刊文献

英文题名：Construction of Benzo[c]carbazoles and Their Antitumor Derivatives through the Diels-Alder Reaction of 2-Alkenylindoles and Arynes

作者：Sha, Feng[1];Tao, Yuan;Tang, Chen-Yu;Zhang, Fei;Wu, Xin-Yan

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：80

期号：16

起止页码：8122

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20153501210072);WOS:【SCI-EXPANDED(收录号:WOS:000360103000030)，CCR-EXPANDED(收录号:WOS:000360103000030)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Project No. 21102043) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Cancer cells - Chemical reactions

摘要：The direct assembly of benzo [c] carbazole derivatives via the Diels-Alder reaction of arynes and easily accessible 2-alkenylidoles was reported. By employing different aryne precursor loads, 6,7-dihydrobenzo[c]carbazoles or arylsubstituted 7,11b-dihydrobenzo[c]carbazoles could be controllably generated in good to excellent yields under a nitrogen atmosphere. On the other hand, when the reaction was conducted under oxygen, oxidated/aromatized product benzo[c] carbazoles could be generated directly with high selectivity and efficiency in a one-step manner. Interestingly, the benzo[c]carbazole-S-carboxamide amidation derivatives of the above products showed good antitumor activities. The inhibitory effect of these molecules against cancer cells was also described.