文献类型：期刊文献

英文题名：Synthesis of β-Silyl α-Amino Acids via Visible-Light-Mediated Hydrosilylation

作者：Wan, Yi[1];Zhu, Jiajie[1];Yuan, Qiyang[1];Wang, Wei[1,2,3];Zhang, Yongqiang[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA;[3]Univ Arizona, BIO5 Inst, Tucson, AZ 85721 USA

年份：2021

卷号：23

期号：4

起止页码：1406

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000629002000046)，CCR-EXPANDED(收录号:WOS:000629002000046)】；

基金：Financial support of this research from the program of National Natural Science Foundation of China (21871086, Y.Z.; 21738002, W.W.) is gratefully acknowledged.

语种：英文

摘要：An expedient synthesis of beta-silyl alpha-amino acids is reported via the application of visible-light-mediated hydrosilylation. The reaction utilizes readily accessible and structurally diverse hydrosilanes to provide radicals for conjugate addition to dehydroalanine ester and analogues. Notably, the use of chiral methyleneoxazolidinone as the substrate and chiral inducer enabled the highly stereoselective synthesis. Furthermore, the reaction could also be performed in a continuous flow fashion and scaled up to the gram scale.