文献类型：期刊文献

英文题名：Macro-mesoporous composites containing PEEK and mesoporous diopside as bone implants: characterization, in vitro mineralization, cytocompatibility, and vascularization potential and osteogenesis in vivo

作者：Cai, Liang[1];Pan, Yongkang[1];Tang, Songchao[1];Li, Quan[2];Tang, Tingting[3];Zheng, Kai[4];Boccaccini, A. R.[4];Wei, Shicheng[5];Wei, Jie[1];Su, Jiacan[2]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed Trauma, Shanghai 200433, Peoples R China;[3]Shanghai Jiao Tong Univ, Dept Orthopaed Surg, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants,Sch Med, Shanghai 200011, Peoples R China;[4]Univ Erlangen Nurnberg, Inst Biomat, Dept Mat Sci & Engn, Cauerstr 6, D-91058 Erlangen, Germany;[5]Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, Lab Interdisciplinary Studies, Beijing 100081, Peoples R China

年份：2017

卷号：5

期号：42

起止页码：8337

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20174504369404);WOS:【SCI-EXPANDED(收录号:WOS:000414156300007)】；

基金：The grants were from the National key research and development program (2016YFC1102100), the National Natural Science Foundation of China (81572194, 51502340 and 81271705), the Major International Joint Research Project between China and Korea (81461148033) and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implants.

语种：英文

外文关键词：Computerized tomography - Sintering - Mesoporous materials - Synchrotron radiation - Compressive strength - Water absorption - Mineralogy - Bone

摘要：Bone implants of polyetheretherketone (PEEK) have become increasingly popular in the orthopedic field but its bioinertness and poor osteogenic properties significantly limit its applications for bone regeneration and osseointegration with host bone. In this study, by incorporation of mesoporous diopside (MD) into the PEEK matrix, macro-mesoporous PEEK/MD (PM) composites as bone implants with interconnected macropores of 300-400 mm were fabricated using the method of cold press-sintering and salt-leaching. The results showed that the compressive strength, porosity and water absorption of the porous PM composites significantly increased with an increase in the MD content. In addition, the incorporation of MD into PEEK obviously enhanced the mineralization ability of the PM composites, indicating good bioactivity. Moreover, the in vitro cell experiments indicated that the macro-mesoporous PM composites significantly promoted the adhesion and proliferation as well as osteogenic differentiation of MC3T3-E1 cells, which depended on the MD content. The results of synchrotron radiation-based micro-computed tomography (SRmCT) and histological analysis revealed that the porous PM composites possessed excellent osteogenic properties in vivo, which were obviously enhanced with an increase in the MD content. Moreover, the immunohistochemistry evaluation of type I collagen (COL I) and vascular endothelial growth factor (VEGF) confirmed that addition of MD into PEEK obviously enhanced the osteogenesis and vascularization potential of the macro-mesoporous PM composites in vivo. The results suggested that the PM composites containing macropores and mesopores as bone implants had great potential for bone repair/substitution.