文献类型：期刊文献

英文题名：Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species

作者：Han, Wen Bo[1,2];Lu, Yan Hua[3];Zhang, Ai Hua[1,2];Zhang, Gao Fei[1];Mei, Ya Ning[4];Jiang, Nan[5];Lei, Xinxiang[6];Song, Yong Chun[1];Ng, Seik Weng[7,8];Tan, Ren Xiang[1]

机构：[1]Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Jiangsu, Peoples R China;[2]Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Nanjing Med Univ, Dept Clin Lab, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China;[5]Nanjing Med Univ, Sch Pharm, Nanjing 210029, Jiangsu, Peoples R China;[6]Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China;[7]Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia;[8]King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia

年份：2014

卷号：16

期号：20

起止页码：5366

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000343526200036)】；

基金：The work was cofinanced by the MOST (2013AA092901), NSFC grants (81121062, 21132004, and 21072092).

语种：英文

摘要：The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.