文献类型：期刊文献

英文题名：Asymmetric Synthesis of cis-3,4-Dihydrocoumarins via [4+2] Cycloadditions Catalyzed by Amidine Derivatives

作者：Jin, Jing-Hai[1,2];Li, Xiang-Yu[1,2];Luo, Xiaoyan[1,2];Fossey, John S.[3];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

年份：2017

卷号：82

期号：10

起止页码：5424

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20172103688046);WOS:【SCI-EXPANDED(收录号:WOS:000402023200043)，CCR-EXPANDED(收录号:WOS:000402023200043)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21372074). J.S.F. thanks the University of Birmingham for support and East China University of Science and Technology for a Guest Professorship.

语种：英文

外文关键词：Cycloaddition - Addition reactions

摘要：A highly efficient chiral amidine derivative-catalyzed tandem Michael addition/lactonization of carboxylic acids and o-quinone methides (o-QMs) has been developed that enables the asymmetric synthesis of cis-3,4-dihydrocoumarins bearing contiguous tertiary stereogenic centers in high yields with excellent stereoselectivities.