文献类型：期刊文献

英文题名：Asymmetric 1,4-Addition of Arylboronic Acids to 2,3-Dihydro-4-pyridones Catalyzed by Axially Chiral NHC-Pd(II) Complexes

作者：Xu, Qin[1,2];Zhang, Rui[1,2];Zhang, Tao[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2010

卷号：75

期号：11

起止页码：3935

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20102312982100);WOS:【SCI-EXPANDED(收录号:WOS:000278063100058)，CCR-EXPANDED(收录号:WOS:000278063100058)】；

基金：We thank the Shanghai Municipal Committee of Science and Technology (06XD14005, 08dj1400100-2), National Basic Research Program of China (973-2010CB833302), and the National Natural Science Foundation of China (20902019, 20872162, 20672127, 20821002, 20732008 and 20702059) for financial support.

语种：英文

外文关键词：Organic compounds

摘要：Axially chiral cis-chelated bidentate bis(N-heterocyclic carbene)-palladium(II) complexes are effective catalysts for the asymmetric conjugate addition of arylboronic acids to 2,3-dihydro-4-pyridones, producing the synthetically and biologically important 2-aryl-4-piperidones in moderate-to-high yields (up to 96%) along with excellent enantioselectivities (up to >99.5% ee) in most cases under mild conditions.