文献类型：期刊文献

中文题名：Microstructure, Content and in vitro Release of Brucine and Strychnine in Strychnos Nux-Vomica Powder with Different Particle Sizes

英文题名：Microstructure, content and in vitro release of brucine and strychnine in Strychnos nux-vomica powder with different particle sizes

作者：Ni, Lijun[1]; Zhao, Wenwen[1]; Zhang, Liguo[1]; Wang, Nannan[1]

机构：[1] School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China

年份：2014

卷号：20

期号：6

起止页码：444

中文期刊名：Transactions of Tianjin University

外文期刊名：Transactions of Tianjin University

收录：EI(收录号：20145000313192);Scopus

基金：Supported by the Plan Issue of Shanghai Science &Technology Committee(No.13401901100)

语种：英文

中文关键词：strychnos;nux-vomica;brucine;strychnine;particle;size;quality;uniformity;in;vitro;release

外文关键词：High performance liquid chromatography - Medicine - Microstructure

摘要：To explore the effect of particle size on the quality uniformity and in vitro release performance of Strychnos nux-vomica powder, seven samples of Strychnos nux-vomica powder with different particle sizes were prepared.Microstructures and particle sizes were analyzed, and high performance liquid chromatography(HPLC) was used to test the contents and in vitro release performances of brucine and strychnine in the samples. Results showed that the contents and the in vitro release rates of brucine(or strychnine) in different samples were different since there are different proportions of endosperms to epidermal cells in Strychnos nux-vomica powder with different particle sizes. Brucine and strychnine in each sample were promptly released in the first ten minutes and their cumulative release rates were higher than 70% after ten minutes. Eighty minutes later, the cumulative release rate tended to be a constant. Considering the quality uniformity and safety of Strychnos nux-vomica powder used as traditional Chinese medicine, it would be better to control the particle size of Strychnos nux-vomica powder between 100 and 140 mesh in which the maximum cumulative release rate in vitro of brucine and strychnine can be relatively low within this range.
To explore the effect of particle size on the quality uniformity and in vitro release performance of Strychnos nux-vomica powder, seven samples of Strychnos nux-vomica powder with different particle sizes were prepared. Microstructures and particle sizes were analyzed, and high performance liquid chromatography (HPLC) was used to test the contents and in vitro release performances of brucine and strychnine in the samples. Results showed that the contents and the in vitro release rates of brucine (or strychnine) in different samples were different since there are different proportions of endosperms to epidermal cells in Strychnos nux-vomica powder with different particle sizes. Brucine and strychnine in each sample were promptly released in the first ten minutes and their cumulative release rates were higher than 70% after ten minutes. Eighty minutes later, the cumulative release rate tended to be a constant. Considering the quality uniformity and safety of Strychnos nux-vomica powder used as traditional Chinese medicine, it would be better to control the particle size of Strychnos nux-vomica powder between 100 and 140 mesh in which the maximum cumulative release rate in vitro of brucine and strychnine can be relatively low within this range. ? 2014, Tianjin University and Springer-Verlag Berlin Heidelberg.