文献类型：期刊文献

英文题名：Synthesis of Core-Shell Structured Dual-Mesoporous Silica Spheres with Tunable Pore Size and Controllable Shell Thickness

作者：Niu, Dechao[1];Ma, Zhi[2];Li, Yongsheng[1];Shi, Jianlin[1,3]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2010

卷号：132

期号：43

起止页码：15144

外文期刊名：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

收录：;EI(收录号：20104513358007);WOS:【SCI-EXPANDED(收录号:WOS:000283621700016)】；

基金：This work was financially supported by the National Hi-Tech Project of China (Grant No. 2007AA03Z317); the National Natural Science Foundation of China (Grant No. 20633090 and 21001043), Scientific Innovation Project of Shanghai Municipal Education Commission (Grant No. 11ZZ53), and Shanghai Pujiang Program (Grant No. 09PJ1403000).

语种：英文

外文关键词：Controlled drug delivery - Block copolymers - Shells (structures) - Magnetite - Mesoporous materials - Pore size - Silica - Hydrophobicity - Magnetite nanoparticles

摘要：Core-shell structured dual-mesoporous silica spheres (DMSS) that possess smaller pores (2.0 nm) in the shell and larger tunable pores (12.8-18.5 nm) in the core have been successfully synthesized by utilizing an amphiphilic block copolymer (polystyrene-b-poly (acrylic acid), PS-b-PAA) and cetyl trimethyl ammonium bromide (CTAB) as cotemplates. The thickness of the shells and the larger pore size in the core could be easily tuned by changing the amounts of TEOS and the hydrophobic block (PS) length during synthesis, respectively. By encapsulating hydrophobic magnetite nanoparticles into the cores, superparamagnetic dual-mesoporous silica spheres were obtained. Drug storage and release testing results showed that the diffusing rate of the stored drug could be efficiently controlled by changing the shell thickness of DMSS.