文献类型：期刊文献

英文题名：Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis

作者：Geng, Zhen[1,3];Ji, Luli[1,3];Li, Zhaoyang[2];Wang, Jing[1,4];He, Hongyan[1,3];Cui, Zhenduo[2];Yang, Xianjin[2];Liu, Changsheng[1,3,4]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]Tianjin Univ, Sch Mat Sci & Engn, Tianjin Key Lab Composite & Funct Mat, Tianjin 300350, Peoples R China;[3]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：6

期号：4

起止页码：905

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000616630300001)】；

基金：This work was financially supported by the National Natural Science Foundation of China for Innovative Research Groups (Grant No. 51621002), China Postdoctoral Science Foundation (Grant No. 2018M640350), National Natural Science Foundation of China (Grant No. 51871163), and Shanghai International S&T Cooperation Project (Grant No.18520710100).

语种：英文

外文关键词：Calcium; Strontium; Mineralization; Osteoclast activity; Osseointegration

摘要：Implant loosening remains a major clinical challenge for osteoporotic patients. This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis, which results in poor bone repair. Strontium (Sr) has been widely accepted as an anti-osteoporosis element. In this study, we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions. The results showed that Ca and Sr exhibited different mineralization behaviors. The main mineralization products for Ca were CaHPO4 center dot 2H(2)O and Ca-3(PO4)(2) with the structure changed from porous to spherical as the pH values increased. The main mineralization products for Sr were SrHPO4 and Sr-5(PO4)(3)OH with the structure changed from flake to needle as the pH values increased. The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion, spreading, proliferation, and osteogenic differentiation. In addition, Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion. Moreover, the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity, improve new bone formation, and enhance bone-implant integration. This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients.