文献类型：期刊文献

英文题名：Dual photo-controlled release system for fipronil and dinotefuran

作者：Fu, Wen[1];Du, Kang[1];Xu, Zhiping[1];Cheng, Jiagao[1];Li, Zhong[1,2];Shao, Xusheng[1,2,3,4]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Frontier Sci Res Base Optogenet Tech Cell, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Sch Pharm, Minist Educ, Shanghai 200237, Peoples R China

年份：2023

卷号：22

期号：4

起止页码：825

外文期刊名：PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

收录：;EI(收录号：20225213308995);WOS:【SCI-EXPANDED(收录号:WOS:000903816900001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Nos. 21877039, 32072441), Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-02-E00037), and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission).

语种：英文

外文关键词：Dual release; TNB-insecticides; Light; Synergistic effect; Pesticide delivery

摘要：Development of controlled release system promises a huge impact on the pesticide delivery, which has raised attentions in improving efficacy of pesticides. Herein, the emerging photoremovable protecting group (PRPG), used in spatiotemporal delivery of drug by light, was introduced into agriculture. We obtained three TNB-insecticides and two of them exhibited excellent photophysicochemical properties. Our dual photo-controlled release system displayed more than sixfold insecticidal activity differences upon irradiation with UV light or sunlight. The dual release of DIN-TNB-DIN showed synergistic effect on mosquito larvae and armyworm larvae. Distribution of the fluorescence in body of dead/alive wigglers clearly illustrated the action mode, and visually demonstrated the precise and spatiotemporal delivery of insecticides in the living mosquito larvae. The new developed dual photo-controlled release system might widen the diversity in pesticide delivery, promoting the development in improving pesticide efficacy.