文献类型：期刊文献

英文题名：Strategy to Tune the Performance of Two Drug Components: Drug-Drug Cocrystals of Lobaplatin with Flavonoids

作者：Yin, He-Mei[1];Xie, Jun-Yi[1];Jiang, Jun-Yi[1];Hong, Minghuang[1];Zhu, Bin[1];Ren, Guo-Bin[1,2];Qi, Ming-Hui[1]

机构：[1]East China Univ Sci & Technol, Shanghai Frontier Sci Res Base Optogenet Tech Cel, Lab Pharmaceut Crystal Engn & Technol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：22

期号：4

起止页码：2602

外文期刊名：CRYSTAL GROWTH & DESIGN

收录：;EI(收录号：20221511945757);WOS:【SCI-EXPANDED(收录号:WOS:000784812500057)】；

基金：This work was supported by the National Natural Science Foundation of China (no. 22078094) and the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission).

语种：英文

外文关键词：Dissolution - Solubility

摘要：A cocrystallization technique was utilized to improve the performance of lobaplatin, and five cocrystals of lobaplatin with a variety of flavonoids, including quercetin, myricetin, fisetin, naringenin, and luteolin, were successfully obtained. The solubility, dissolution, and stability of the cocrystals were further evaluated, the results presented that the cocrystals have reduced solubilities, slow-release rates, and delayed hydrolysis performances compared to lobaplatin. Meanwhile, the solubilities and dissolution rates of the flavonoids were dramatically improved. In addition, CCK-8 assay was used to evaluate the antitumor activity of the cocrystals, which shows that the cocrystals of lobaplatin-luteolin monohydrate, lobaplatinmyricetin monohydrate, and lobaplatin-fisetin monohydrate exhibit superior performances to lobaplatin. These findings may provide a promising solution for overcoming some weaknesses of the parent drugs.