文献类型：期刊文献

英文题名：Synthesis of 1,3-dithiolane-containing nitromethene compounds and their biological activity as insecticides

作者：Li, Dongmei[1];Tian, Zhongzhen[1];Xu, Zhiping[2];Wang, Gaolei[2]

机构：[1]Univ Jinan, Sch Chem & Chem Engn, Shandong Prov Key Lab Fluorine Chem & Chem Mat, Jinan 250022, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2013

卷号：39

期号：5

起止页码：2063

外文期刊名：RESEARCH ON CHEMICAL INTERMEDIATES

收录：;EI(收录号：20131716245350);WOS:【SCI-EXPANDED(收录号:WOS:000317622700012)】；

基金：We thank the National Science Foundation China Program (grant 20902037), the Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (grant BS2010NY001), and the Opening Fund of Shanghai Key Laboratory of Chemical Biology (grant SKLCB-2008-08).

语种：英文

外文关键词：Neonicotinoid; Insecticides; 1,3-Dithiolane; Biological activity

摘要：1,3-Dithiolane-containing nitromethylene derivatives, as candidates for screening as neonicotinoid insecticides, were synthesized by reaction of compound (4) with 1,2-ethanedithiol. Compounds 7a-g were obtained via Mannich reaction of (E)-1-((1,3-dithiolan-2-yl)methyl)-2-(nitromethylene)imidazolidine (6), primary amines and formaldehyde. The synthesized compounds were identified by H-1 NMR, IR spectroscopy and elemental analysis. Preliminary bioassays indicated that most of the compounds had moderate insecticidal activity against Aphis craccivora. The relationship between molecular structure and biological activity is discussed.