文献类型：期刊文献

英文题名：Antibacterial Zwitterionic Polyelectrolyte Hydrogel Adhesives with Adhesion Strength Mediated by Electrostatic Mismatch

作者：Wang, Jintao[1,2,3];Wang, Liufang[1,2];Wu, Changsong[4];Pei, Xinjie[3];Cong, Yang[4];Zhang, Rui[1,2];Fu, Jun[3]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Large Scale Reactor Engn, Minist Educ, Sch Chem Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Engn Res Ctr Large Scale Reactor Engn & Technol, Minist Educ, Sch Chem Engn, Shanghai 200237, Peoples R China;[3]Sun Yat Sen Univ, Sch Mat Sci & Engn, Guangzhou 510275, Peoples R China;[4]Ningbo Univ Technol, Sch Mat Sci & Chem Engn, Ningbo 315201, Peoples R China

年份：2020

卷号：12

期号：41

起止页码：46816

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20204409436215);WOS:【SCI-EXPANDED(收录号:WOS:000582345700112)】；

基金：This study was supported by National Natural Science Foundation of China (51873224) and the Ministry of Industry and Information Technology of China (TC90HZV/1).

语种：英文

外文关键词：hydrogel; adhesion; antibacterial properties; zwitterionic; wound healing

摘要：Biotissue adhesives and antibacterial materials have great potential applications in wound dressing, implantable devices, and bioelectronics. In this study, stretchable tissue adhesive hydrogels with intrinsic antibacterial properties have been demonstrated by copolymerizing zwitterionic monomers with ionic monomers. The hydrogels are stretchable to about 900% strain and show a modulus of 4-9 kPa. The zwitterionic moieties provide strong dipole-dipole interaction, electrostatic interaction, and hydrogen bonding with the skin surface, and thus show adhesion strength values of 1-4 kPa to skin. Meanwhile, the copolymerized cationic or anionic monomers break the intrinsic electrostatic stoichiometry of the zwitterionic units and thus mediate the electrostatic interactions and the adhesion strength with the surface. The stretchable hydrogels form a robust and compliant (due to low modulus and stretchability) adhesive to skin, rubber, glass, and plastics, and could be repeatedly peeled-off and readhered to the skin. Moreover, the abundant quaternary ammonium (QA) groups in the zwitterionic moieties and the added QA groups endow it outstanding antibacterial properties (>99%). These stretchable tissue adhesive antibacterial hydrogels are promising for wound dressings and implantable devices.