文献类型：期刊文献

英文题名：Magnetic Properties of Al3+ Ion Solid-Solid Doped Fe3o4 and Biological Applications of Gqds Grafted Mnps

作者：Huan, Wei-Wei[1]; Dong, Meng-Yang[2]; Guan, Yuxia[2]; Xie, Meng[3]; Huang, Yan[2]; Carlini, Riccardo[4]; Yang, Yu-Xiang[2]

机构：[1] Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, College of Chemistry and Materials Engineering, Zhejiang A & F University, Zhejiang, Hangzhou, 311300, China; [2] School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai, 200237, China; [3] School of Pharmacy, Jiangsu University, Jiangsu Province, 212013, China; [4] Chemistry and Material Chemistry Department, LAS Klee-Barabino, Genova, 16146, Italy

年份：2023

外文期刊名：SSRN

收录：EI(收录号：20230280110)

语种：英文

外文关键词：Aluminum - Aluminum coatings - Grafting (chemical) - Grinding (machining) - Magnetic properties - Magnetite - Mammals - Saturation magnetization - Silica - Silicon

摘要：Strong magnetic nanoparticles doped by nonmagnetic ions of Al3+ were prepared by solid-solid grinding of as-prepared Fe3O4 magnetic nanoparticles with aluminum formic acid hydrazide. HRTEM, XRD, M?ssbaure spectrum and VSM were used to characterize the morphology, structure, magnetic properties of doped magnetic particles, and their doping mechanism. 2.79% Al doped magnetic nanoparticles (MNPs) showing the largest saturation magnetization value (82.3 emu/g) were chosen to be further coated with silica shell. Then GQDs grafted 2.79% Al doped MNPs@SiO2 were employed to label 99mTc for targeting in vivo: mice were in vivo used as animal model to study biological application of 99mTc labeled GQDs-Al doped NMPs: A higher magnetic response effect under pulsed magnetic gradient field of targeted functionalized Al doped magnetic particles was observed. The obtained data from both control group and experimental group indicated that the uptake ability of radioactivity in the liver of New Zealand rabbits via the magnetic targeted intervention is 3.69 times higher than that achieved in the liver of the New Zealand rabbits without magnetic targeted intervention. ? 2023, The Authors. All rights reserved.